You should not be treated with Kcentra if you have: After you are treated with this medicine, do not start using your blood thinner again until your doctor tells you to. Kcentra is for use in people who use blood thinners such as warfarin. Tell your doctor if you have ever had a heart attack, stroke, TIA or "mini-stroke", chest pain, severe circulation problems, or a blood clot (especially within the past 3 months). While using Kcentra, tell your caregivers right away if you have signs of a blood clot: sudden numbness or weakness, problems with vision or speech, chest pain, cough, wheezing, rapid breathing, swelling or pain in your arms, legs, or stomach. Kcentra is for use in adults and dosing is based on body weight. Kcentra is used to quickly reverse the effects of a blood-thinning medicine (such as warfarin) during a major bleeding episode, or when there is a need for emergency surgery or invasive medical procedure. Kcentra is a blood coagulation factor replacement product. Medically reviewed by Philip Thornton, DipPharm. Subcutaneous administration should only be considered when a patient is unable to tolerate oral vitamin K therapy and is not clinically compromised enough to necessitate IV vitamin K 1.Generic name: prothrombin complex ĭrug class: Anticoagulant reversal agents Because intravenous (IV) administration of vitamin K 1 may be associated with anaphylactoid reactions, it should be avoided unless serious or life-threatening bleeding is present. 1 Oral administration of vitamin K 1 is safe and effective. The optimal dosage regimen of vitamin K 1 to treat patients who develop an elevated INR while receiving warfarin is given in the 2012 American College of Chest Physicians consensus guidelines. Acquired vitamin K deficiency typically results from the therapeutic administration of warfarin, or following the overdose of warfarin or a long-acting anticoagulant rodenticide (LAARs), such as brodifacoum. Vitamin K 1 (phytonadione) is the commercial preparation of the natural form of vitamin K (phylloquinone) that is indicated for the reversal of an elevated prothrombin time (PT) or an international normalized ratio (INR) in patients with xenobiotic induced vitamin K deficiency.
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